I am reading with interest your recent paper (Kumar, Clarke, and Gerstein, PNAS), but I suspect that supplement 1 and 2 are the same, and neither has a list of 434 genes. Could you please supply the list?
Thank you very much for your interest in the paper. Supplement 1 includes hotspot communities based on pan-cancer analysis (i.e., when will compute statistics over multiple cancer cohorts in TCGA). In contrast, supplement 2 lists out putative driver genes with hotspot communities for specific cancer types. If you note in supplement2, column F list out the name of particular cancer cohorts.
Regarding the number of genes, 434 genes are based on the pan-cancer analysis.
For each gene, there are multiple PDB entries. For analysis in our paper, we selected a representative structure with the highest residue coverage. However, to be exhaustive and allow researchers to analyze protein of their interest, in our supplement, we include all PDB entries for a given gene. We have tried to explain this in our method section.
Thanks for your quick reply; but, no, this does not remove my confusion. Please take a moment to check the link from your paper at PNAS. When I download pnas.1901156116.sd01.xlsx, the file has 217 lines (not 434) and includes the column F that breaksdown by cancer type.
I am attaching our original tables with the email. It appears that the table has been somehow duplicated on the PNAS website. We will work with the PNAS team to get it fixed.
I am reading your Hinge Atlas (2007) paper.
I searched for your dataset to study the pdb structures you used and their
hinge residues, but I could not download it from the page:
Could you please send a file if it is possible by email, or please check and
fix if there is a bug on the web page.
Please try the Hinge Atlas Gold while we investigate the webpage. This may take time.
I tried to use the 3V (http://3vee.molmovdb.org/) server developed at your lab but I was not able to connect to it. Is the server still running? Would you help me find a way to run it?
It was up but unresponsive. It should be working now.
Could you please have a look at my submission from yesterday and tell me what I did wrong that they job does not finish?
The server is running fine. Please follow the tutorial vedio for input file preparations. We are not responsible for user’a input files that are not compatible with the original script of the server.
We do not run jobs for those users, given that the server runs fine as it is originally supposed to be. There’s FAQ and tutorial I made on the webpage that you should follow.
I am writing this e-mail to inquire about STRESS software.
We have learned from your paper (Structure 2016,24:826-837)
that STRESS software can be used for identifying allosteric pockets.
We are interested in using the software for our drug discovery research.
We will perform evaluation of the software for a start.
Will you allow us to use STRESS software for the purpose of our
commercial drug discovery project free of charge?
As this is an urgent project, we would highly appreciate if you could
see license at https://sites.gersteinlab.org/permissions/
We could not access your 3V server listed in your paper below.
Link to such calculation of protein volume in the presence of probe with
Should be up now. We had to power down all our machines on Monday and
3vee went up but it was in a hung state.
I have read with interest about the Helix Interaction Tool and am interested in it to calculate helix crossing angles in simple proteins. How does one access the web server?