Regulatory Genetic network AND DSPN

I am studying your publication in Science (Comprehensive functional genomic resource and integrative model for the human brain, Science 362,1266(2018) with great interest. As a quantitative geneticist, I found it very relevant to the study of complex genetic traits. Therefore, I am writing this note to request your assistance inorder get your software/algorithm for Regulatory Genetic Network modeling and Integrative deep learning model (DSPN) so that we could implement them at NIH supercomputer system and conduct some integrative genomic modeling work in the area of brain/neuropsychiatry.

Best to see Specifically — you can find the matlab codes "7. Matlab code and formatted data for
the DSPN" on

Request for the supplementary data of the ENCODE paper

My projects focus on exploring the mechanisms of gene regulation. I recently read the ENCODE paper (Architecture of the human regulatory network derived from ENCODE data, 2012) again and realized that the supplementary data will greatly help us to refine our results.

Unfortunately, I found that all the files have been achieved. Both of the following sites can’t be reached. I am writing to ask if there are any other ways to access the files. Thank you very much for your time. I am looking forward to hearing from you.

should be up shortly

Inquiry about STRESS

I am writing this e-mail to inquire about STRESS software.

We have learned from your paper (Structure 2016,24:826-837)
that STRESS software can be used for identifying allosteric pockets.
We are interested in using the software for our drug discovery research.
We will perform evaluation of the software for a start.

Will you allow us to use STRESS software for the purpose of our
commercial drug discovery project free of charge?

As this is an urgent project, we would highly appreciate if you could
reply soon.

see license at