Q:

I read your paper about the co-associations among TF binding events, (Architecture of the human regulatory network derived from ENCODE data), and got interested in your original clustering algorithm. Now, in our laboratory, we are developing a new clustering algorithm for a large number of genomic data, and implemented its prototype algorithm. However, the accuracy of our algorithm is not so completed, and we have to evaluate it. Thus, we want to use your algorithm as the fine basis, so how can we use it? If the program is available for us, can you tell us the way to use it?

A:

In that paper we used the Rulefit3 package from Prof. Jerome Friedman; there is an R package available at the link below. Our use of the algorithm is extensively documented in Section C of the Supplementary Materials.

Rulefit3

http://dx.doi.org/10.1214/07-Aoas148

http://www-stat.stanford.edu/~jhf/r-rulefit/rulefit3/R_RuleFit3.html

Architecture of the human regulatory network derived from ENCODE data http://dx.doi.org/10.1038/Nature11245