Q:
I’m quite interested in the cost of sequencing for a genome. I read the
paper "The real cost of sequencing: higher than you think! " which published
on <Genome Biology>. It’s a good paper but the author didn’t separate the
cost of library preparation from the cost of running the sequencer. So my
question is from your experience, could you tell me the ration of the cost
of library preparation to the cost of running the sequencer. It’s quite
important for me to design a experiment.

A:
as indicated in the paper, the two numbers you mentioned regard the cost of library prepration ($500) and the cost running the sequencer ($6000), respectively. Note that current figures may be different.