Zebrafish pseudogenes

In Pseudogene.org, the pseudogene datasets of zebrafish (Danio rerio) was based on old annotations (Ensembl 55?). There were about ~1800 processed pseudogenes. However, based on a recent research (http://www.nature.com/nature/journal/v496/n7446/full/nature12111.html), there were rare pseudogenes in zebrafish. (Only 21 processed pseudogenes, according to Supplementary Table 14 in the published manuscript). Is this great conflict due to the old annotations?

This is right, the results were based on an old genome assembly, ENSEMBL release 55, which was done in year 2009. We do notice that the pseudogene number is way too high, which we believe partially due to the quality of the genome assembly, and partially due to the reason that the pipeline parameters were optimized with primates. Given that, for up-to-date pseudogene information in Zebrafish, people should refer to the Nature publication.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s